Association between the Met326Ile polymorphism of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase and prostate cancer risk: a prospective study.
نویسندگان
چکیده
The Lank Center for Genitourinary Oncology, Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115 [A. E. P., P. W. K.]; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115 [M. J. S., E. G., J. M.]; and Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts 02115 [M. J. S., E. G., J. M.]
منابع مشابه
Association between phosphatidylinositol 3-kinase regulatory subunit p85alpha Met326Ile genetic polymorphism and colon cancer risk.
PURPOSE The phosphatidylinositol 3-kinase signaling pathway is frequently activated in cancer. Emerging evidence supports the p85alpha regulatory subunit gene, PIK3R1, as a novel oncogene. EXPERIMENTAL DESIGN We examined the association of a functional missense polymorphism (Met326Ile) of PIK3R1 with colon cancer risk in a population-based case-control study of 421 incident cases and 483 cont...
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Background and Objective: Prostate cancer is among the five common cancers in males. It is second cancer in terms of the age-standardized rate (ASR) (ASR=16.6) in Iran. The rs2735839 G/A, an intergenic polymorphism is located on chromosome 19q13.33 at 600 base pairs of the KLK3 gene untranslatable region. This gene which codes prostate-specific antigen (PSA) is used in the screening and diagnos...
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Spinal muscular atrophy (SMA) is a frequent neuromuscular disorder caused by motoneuronal apoptosis, as a result of SMN (Survival Motor Neuron) protein deficiency. Although the SMA determining gene was identified, the molecular mechanism of the disease is not clearly understood, due to the heterogeneity of clinical manifestations. Trying to complete the molecular describing SMA picture, by iden...
متن کاملGenetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease.
OBJECTIVE To test the hypothesis that polymorphic variation in insulin signalling genes may underlie the shared risk of dysfunctional insulin signalling and late onset Alzheimer's disease (AD). The p85alpha subunit of phosphatidyl inositol 3 kinase (PIK3R1) and the regulatory subunit 3 of protein phosphatase 1 (PPP1R3) were selected as candidate genes because both encode key proteins involved i...
متن کاملAssociation of rs9122 Polymorphism in the MCC Gene with Increasing the Risk of Gastric Cancer
Abstract Background and Aim: Gastric cancer is one of the most common malignancies in the world. Genetic background is known to be one of the risk factors for gastric cancer. One of the genes that have been shown to be involved in various cancers, including gastric cancer, is the MCC gene. There are many SNPs in the MCC gene in the encoding and regulatory regions, one of which is rs9122, which ...
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عنوان ژورنال:
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
دوره 12 2 شماره
صفحات -
تاریخ انتشار 2003